Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis

Background: Although it has been suggested that hyperuricemia and gout are predictive of the future risk atrial fibrillation, there is still a lack epidemiological evidence. Objective: Through an updated systematic review meta-analysis, we aimed to assess association between hyperuricemia/gout fibrillation. Methods: We performed search EMBASE, PubMed, Web Science from their establishment September 2021 for all relevant studies or Meta-analysis was conducted using random-effects method calculate overall relative (RR) 95% confidence intervals (CI), subgroup analyses were on data subsets by geographic location study design. Result: A total 12 included in this study. The results 8 showed associated with increased incidence fibrillation (RR: 1.83, CI: 1.35–2.47), but significant only observed China 1.88, 1.31–2.71) cross-sectional 2.35, 1.97–2.81) rather than Japan 1.74, 0.71–4.23) cohort 1.20, 0.99–1.46). 4 also AF 1.33, 1.04–1.71). Conclusions: Hyperuricemia